Spatially and temporally restricted expression of Hox genes requires multiple mechanisms at both the transcriptional and the post-transcriptional levels. New insight into this precise expression mechanism comes from recent findings of a novel sense–antisense miRNA combination from the bithorax complex of Drosophila melanogaster.1-4 These two miRNAs encoded from the same locus target 3′ untranslated regions of anterior hox genes, Antp, Ubx and abd-A to establish the dominance of posterior hox gene Abd-B in its expression domain. Such double-edge tools, sense–antisense miRNA (...) combinations, also operate at multiple loci in the genome implicating their wider impact on the post-transcriptional gene regulation in eukaryotes. BioEssays 30:1058–1061, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Contributed articles presented at the National Workshop on "Innovative Courses on Applied/Practical Philosophy" held on Dec. 10-12, 2001 organized by Indian Council of Philosophical Research.

In this paper, I’ll discuss the philosophical debate that took place between Michel Foucault and his student Jacques Derrida on Rene Descartes’ doctrine of cogito. In my exposition, I shall discuss Descartes’ contributions to modern philosophy in twofold manner, namely the central and the marginal doctrines. At the centre of Cartesian modernity, there is cogito and the emergence of human subjectivity, reason and rationalism, truth in terms of clearness and distinctness and the existence of God. On the margins, we come (...) across madness, deception, demon and so forth. These are the issues, which are subjected to rigorous criticism and rejection by Foucault on the one hand, and Derrida on the other. The debate tries to reallocate the central and the marginal themes by overemphasizing the marginal issues and thereby moving one step forward. However, in the process of doing that they have under-emphasized the central doctrines and have gone two steps backward. The ambition lies in paving the way for an internal departure from Cartesian modernity to Foucauldian–Derridean postmodernity. Instead of going to a critical reading of Derrida’s interpretation of the Cartesian text step by step and his debate with Foucault, the present paper hopes to provide some of the basic issues involved in Descartes and Foucauldian–Derridean reaction to those issues. In my attempt to articulate the debate, I shall furnish some clarifications, annotations and summations that may be useful for the limited end of preliminary acquaintance with Descartes on the one hand, and Foucault and Derrida on the other. (shrink)

It is often argued that the indispensability of continuum models comes from their empirical adequacy despite their decoupling from the microscopic details of the modelled physical system. There is thus a commonly held misconception that temperature varying across a region of space or time can always be accurately represented as a continuous function. We discuss three inter-related cases of temperature modelling — in phase transitions, thermal boundary resistance and slip flows — and show that the continuum view is fallacious on (...) the ground that the microscopic details of a physical system are not necessarily decoupled from continuum models. We show how temperature discontinuities are present in both data (experiments and simulations) and phenomena (theory and models) and how discontinuum models of temperature variation may have greater empirical adequacy and explanatory power. The conclusions of our paper are: a) continuum idealisations are not indispensable to modelling physical phenomena and both continuous and discontinuous representations of phenomena work depending on the context; b) temperature is not necessarily a continuously defined function in our best scientific representations of the world; and c) that its continuity, where applicable, is a contingent matter. We also raise a question as to whether discontinuous representations should be considered truly de-idealised descriptions of physical phenomena. (shrink)

So-called ‘distinctively mathematical explanations’ (DMEs) are said to explain physical phenomena, not in terms of contingent causal laws, but rather in terms of mathematical necessities that constrain the physical system in question. Lange argues that the existence of four or more equilibrium positions of any double pendulum has a DME. Here we refute both Lange’s claim itself and a strengthened and extended version of the claim that would pertain to any n-tuple pendulum system on the ground that such explanations are (...) actually causal explanations in disguise and their associated modal conditionals are not general enough to explain the said features of such dynamical systems. We argue and show that if circumscribing the antecedent for a necessarily true conditional in such explanations involves making a causal analysis of the problem, then the resulting explanation is not distinctively mathematical or non-causal. Our argument generalises to other dynamical systems that may have purported DMEs analogous to the one proposed by Lange, and even to some other counterfactual accounts of non-causal explanation given by Reutlinger and Rice. (shrink)

(Longer version - work in progress) Various accounts of distinctively mathematical explanations (DMEs) of complex systems have been proposed recently which bypass the contingent causal laws and appeal primarily to mathematical necessities constraining the system. These necessities are considered to be modally exalted in that they obtain with a greater necessity than the ordinary laws of nature (Lange 2016). This paper focuses on DMEs of the number of equilibrium positions of n-tuple pendulum systems and considers several different DMEs of these (...) systems which bypass causal features. It then argues that there is a tension between the modal strength of these DMEs and their epistemic hooking, and we are forced to choose between (a) a purported DME with greater modal strength and wider applicability but poor epistemic hooking, or (b) a narrowly applicable DME with lesser modal strength but with the right kind of epistemic hooking. It also aims to show why some kind of DMEs may be unappealing for working scientists despite their strong modality, and why some DMEs fail to be modally robust because of making ill-informed assumptions about their target systems. The broader goal is to show why such tensions weaken the case for DMEs for pendulum systems in general. (shrink)

Along with economic strength, space technology and software expertise, India is also a leading nation in fraudulent scientific research. The problem is worsened by vested interests working in concert for their own benefits. These self-promoting cartels, together with biased evaluation methods and weak penal systems, combine to perpetuate scientific misconduct. Some of these issues are discussed in this commentary, with supporting examples and possible solutions.

herent and rational way. Several proposals have been made for information merging in which it is possible to encode the preferences of sources (Benferhat, Dubois, Prade, & Williams, 1999; Benferhat, Dubois, Kaci, & Prade, 2000; Lafage & Lang, 2000; Meyer, 2000, 2001; Andreka, Ryan, & Schobbens, 2001). Information merging has much in common with social choice theory, which aims to define operations reflecting the preferences of a society from the individual preferences of the members of the society. Given this connection, (...) frameworks for information merging should provide satisfactory resolutions of problems raised in social choice theory. We investigate the link between the merging of epistemic states and two important results in social choice theory. We show that Arrow’s well-known impossibility theorem (Arrow, 1963) does not hold in merging frameworks when the preferences of sources are represented in terms of epistemic states. This is achieved by providing a consistent set of properties for merging from which Arrow-like properties can be derived. Similarly, by extending these to a consistent framework which includes properties corresponding to the notion of being strategy-proof, we show that results due to Gibbard and Satterthwaite (Gibbard, 1973; Satterthwaite, 1973, 1975) and other (Benoit, 2000; Barber´a, Dutta, & Sen, 2000) do not hold in merging frameworks. (shrink)

The paper seeks to understand India’s evolving rights framework in the backdrop of cow vigilantism. To that end it discusses the human right to food and nutrition, international discussion on minority rights issues in India and the relevant legal and constitutional discussion in India. It finds that India’s rights framework has evolved since proclamation of India as a Republic in 1950 based on the supremacy of its written constitution containing fundamental rights and directive principles of state policy interpreted finally by (...) its Supreme Court. The government took a wise step by not challenging a judicial rebalancing of the rights framework in response to certain executive measures and the Supreme Court interpreted the right to life to include not only the right to the choice of food but also the right to privacy and thereby underscored the obligation of the State to compensate the victims of cow vigilante violence. However, a constitutional polity and secular state would do all well if it did any further necessary to better guard against any recurrence of the breach of civil peace, much less violence, on purely secular issues, including by strengthening and increasing dialogue with all representative communities in all its decision-making on such matters. (shrink)

What I require is a convening of my culture's criteria, in order to confront them with my words and life as I pursue them and as I may pursue them; and at the same time to confront my words and life as I pursue them with the life my culture's words may imagine for me: to confront the culture with itself, along the lines it meets in me. Stanley Cavell.

This book takes as its point of departure a humble cell lying on the intersection of ideas as diverse and yet interlaced as life, knowledge, commerce, governance, and ethics. It seeks to deepen the understanding of stem cell entities and the concerns, hopes, and aspirations that shape and make them viable therapeutic entities in the context of rapid globalization. Several key intersections between individual, group, and institutional relationships have become central to locating and debating the production of stem cells today. (...) This edited collection addresses three overarching concerns: regenerating the notion of ethics, the emerging therapeutic horizons, and the position of the patient. As a whole this book seeks to explain how stem cells are accommodated, contested, and used in contemporary India and around the globe through an informed unpacking of issues underpinning contestation and promotion bestriding these technological developments. The authors offer a truly multi-disciplinary perspective, stimulating conversation between the social sciences, biological sciences and the patient. The concerns expressed and highlighted by these conversations are embedded in a vast geo-political expanse stretching from India to Euro-America and will be of great interest to academics and practitioners across fields including science technology studies, medicine and international development. (shrink)

A reasoned argument or tarka is essential for a wholesome vāda that aims at establishing the truth. A strong tarka constitutes of a number of elements including an anumāna based on a valid hetu. Several scholars, such as Dharmakīrti, Vasubandhu and Dignāga, have worked on theories for the establishment of a valid hetu to distinguish it from an invalid one. This paper aims to interpret Dignāga’s hetu-cakra, called the wheel of grounds, from a modern philosophical perspective by deconstructing it into (...) a simple probabilistic mathematical model. The objective is to understand how and why a vāda based on a probabilistically weaker hetu can degrade into a Jalpa or vitaṇḍā. To do so, the paper maps the concept of ‘Bounded Rationality’ onto the hetu-cakra. Bounded Rationality, an idea coined by the management thinker Herbert Simon, is often employed in understanding decision-making processes of rational agents. In the context of this paper, the concept would state that the prativādin and ālocaka (debater) may not hold unbounded information to back their pratijñā (proposition). The paper argues that within the probabilistically deconstructed hetu-cakra model, most people argue in the ‘Zone of Bounded Rationality’, and thus, the probability of a debate degrading into Jalpa or vitaṇḍā is high. -/- . (shrink)

Kajian ini mengangkat pemikiran dua filsuf besar yaitu Martin Heidegger dan Mullā Şadrā dalam suatu kajian Filsafat Manusia dengan topik pembahasan ‘Struktur Fundamental Manusia’. Problem yang diangkat adalah bagaimana kesejalanan atau paralelisme gagasan keduanya mengenai struktur fundamental manusia. Penelitian ini berusaha mencari hakikat manusia menurut pandangan Martin Heidegger dan Mullā Şadrā kemudian mensintesiskannya dengan metode paralelisme. Penelitian ini penulis rasa penting, di samping untuk memperkaya dialog pemikiran antar peradaban, juga karena kedua filsuf ini memiliki kesamaan prinsip ontologis dalam fondasi filsafatnya (...) yaitu, Ada. Pandangan ini kemudian disebut dengan ‘reduksi ontologis’. Keduanya yakin bahwa tidak ada problem filsafat yang dapat terselesaikan kecuali pertanyaan tentang Ada terjawab secara memadai. Pandangan reduksi ontologis ini termanifes dalam bangunan pemikiran dan kritik keduanya, terutama dalam studi ini adalah gagasan mengenai manusia yang bersandar pada prinsip ke swa-buktian Ada. Metode yang digunakan dalam penelitian ini ialah metode komparatif khusus yaitu Paralelisme. Paralelisme adalah teori interpretasi atau metode komparasi khusus yang berupaya mencari paralelitas atau kesejalanan formulasi pemikiran antara dua filsuf yang memiliki perbedaan konteks, penekanan, pendekatan arah pemikiran dan solusi, namun memiliki karakteristik gagasan yang sejalan, sebangun atau paralel. Dari penelitian ini penulis menyimpulakan bahwa, Paralelisme Struktur Fundamental Manusia menurut Heidegger dan Mullā Şadrā menunjukan suatu kritik pada pandangan yang telah mengakar dalam diskursus filsafat Barat modern yang dipelopori oleh Rene Descartes. Heidegger secara terang menunjukan ketidakterimaannya pada pandangan tentang diri dalam filsafat Cartesian dan mendobraknya dengan gagasan manusia Dasein sebagai eksisten yang memahami dirinya sendiri dalam pra-struktur memahami, secara eksistensial dan mendahului suatu refleksi atau aktifitas kognitif apapun tentang diri Aku. Demikian pula Mullā Şadrā, walaupun hidup seabad dengan Rene Descartes, secara tidak langung mengkritik tradisi filsafat rasionalisme semacam itu dengan mengembangkan gagasan ilmu ḥudhūrī-nya, bahwa pengetahuan akan Aku atau diri ini bersifat imanen dalam dirinya sendiri dan mendahului segala bentuk konsepsi atau refleksi mengenai diri serta menjadi dasar bagi pengetahuan empiris. (shrink)

Corporate social responsibility (CSR) is a comprehensive concept that aims at the promotion of responsible business practices closely linked to the strategy of enterprises. Although there is no single accepted definition of CSR, it remains an inspiring, challenging and strategic development that is becoming an increasingly important priority for companies of all sizes and types, particularly in Europe. Promotion of well-being at work is an essential component of CSR; however, the link between CSR, working conditions and work organisation is still (...) found to be unfamiliar to stakeholders. As CSR is strategic and is regarded by many companies and corporate leaders as an important development, it offers opportunities for psychosocial risk management, an area that is currently among the top priorities in working environment and well-being at work debates. However, the link between CSR and psychosocial risk management has not been addressed clearly before. This paper aims to explore the potential role of CSR in promoting well-being at work through the development of a framework for the management of psychosocial risks. As part of the research, key stakeholders [including the World Health Organization (WHO), the International Labour Organization (ILO), the European Agency for Safety and Health at Work (EU-OSHA), the European Commission (EC), employers’ associations, trade unions and other policy experts] across Europe participated in a survey, interviews and focus groups to assess and clarify the link between CSR and psychosocial risk management. On the basis of the findings, a CSR-inspired approach to the management of psychosocial issues at work is proposed. Such an approach can be a useful tool in contexts where, up until now, expertise and tradition in dealing with psychosocial issues have been lacking. (shrink)

Traditional accounts of belief change have been criticized for placing undue emphasis on the new belief provided as input. A recent proposal to address such issues is a framework for non-prioritized belief change based on default theories (Ghose and Goebel, 1998). A novel feature of this approach is the introduction of disbeliefs alongside beliefs which allows for a view of belief contraction as independently useful, instead of just being seen as an intermediate step in the process of belief revision. This (...) approach is, however, restrictive in assuming a linear ordering of reliability on the received inputs. In this paper, we replace the linear ordering with a preference ranking on inputs from which a total preorder on inputs can be induced. This extension brings along with it the problem of dealing with inputs of equal rank. We provide a semantic solution to this problem which contains, as a special case, AGM belief change on closed theories. (shrink)

Our concern in this paper lies with a common argument from racial discrimination to realism about races: some people are discriminated against for being members of a particular race (i.e., racial discrimination exists), so some people must be members of that race (i.e., races exist). Error theorists have long responded that we can explain racial discrimination in terms of racial attitudes alone, so we need not explain it in terms of race itself. But to date there has been little detailed (...) discussion of whether it is better to explain racial discrimination in terms of race or in terms of racial attitudes alone. Our goal is to offer a novel and detailed argument in defense of explaining racial discrimination in terms of racial attitudes alone, by attending to the neglected phenomenon of misperception discrimination, which involves differential treatment due to misperceived race. We argue that the discriminatory action in misperception cases must be explained in the same way as cases where (according to the realist) the victim’s race is accurately perceived. Thus, the victim’s actual race cannot provide the best explanation. The main upshot of our argument is that explanatory arguments from racial discrimination to realism about race fail. (shrink)

During the COVID-19 pandemic, many religious college students have found comfort in God, while others may have developed anger toward God; however, no studies have systematically compared the multidimensional effects of religiousness on how Muslim and Christian students react to stressors such as COVID-19. This study addressed this gap in the literature by investigating which of the Four Basic Dimensions of Religiousness Scale were significant predictors for both taking comfort in and feeling anger toward God among Muslim and Christian college (...) students in Indonesia, while also controlling for the influence of neuroticism, a known predictor for attitudes toward God. Muslims reported that all dimensions of the 4-BDRS were significant predictors of comfort, with bonding as a negative predictor, while Christians reported that belonging was the only insignificant predictor. Muslims reported that believing and behaving were negative predictors of anger, while Christians reported negative effects only for bonding ; however, bonding did not significantly predict anger when analyzed separately for men and women. Therefore, to decrease their anger toward and increase the comfort they find in God, Muslims must focus on their beliefs and exercise the commandments of Islam. Christians, though, must focus on increasing cognitive, affective, and behavioral aspects of religiousness to find comfort, while having better personal relationships with God could be key in reducing anger toward God. (shrink)

Academic dishonesty and cheating by students has become endemic in higher education. In this article, we conducted a study on undergraduate business students (n = 162) to examine the impact of business ethics education and ethics training on student attitudes towards academic dishonesty as well as their cheating behaviors. We found that business ethics education in conjunction with business ethics training had a positive impact on students’ attitudes towardsacademic dishonesty and cheating; however there was no significant impact of either business (...) ethics education or training on actual cheating behaviors. In our discussion we suggest some implications of our findings, and make some suggestions about future research directions. (shrink)

This paper argues that Weber ought to be read as a comparative ethicist who brings his German intellectual inheritance, especially Schopenauer and Nietzsche, to a dialogue with ethical traditions in India and China. It shows that Weber not only had a supple understanding of the tensions within Hindu ethics, his own account of value often closely corresponds to Hindu axiology and was enriched by an encounter with it.

Academic dishonesty and cheating by students has become endemic in higher education. In this article, we conducted a study on undergraduate business students (n = 162) to examine the impact of business ethics education and ethics training on student attitudes towards academic dishonesty as well as their cheating behaviors. We found that business ethics education in conjunction with business ethics training had a positive impact on students’ attitudes towardsacademic dishonesty and cheating; however there was no significant impact of either business (...) ethics education or training on actual cheating behaviors. In our discussion we suggest some implications of our findings, and make some suggestions about future research directions. (shrink)

This article provides a comprehensive review of the literature on academic dishonesty and cheating. The different kinds of cheating behaviors and the factors associated with them are delineated and described. Suggestions are provided on how to take corrective and proactive decisions to control and thereby reduce academic dishonesty and cheating.

The name of the second author was incorrect in the initial online publication. The original article has been corrected.

In this paper, we examine the relationships between three of the Big 5 personality traits and willingness to justify unethical behavior. We also consider the moderating relationship of four of the GLOBE cultural dimensions on the above relationship. We tested our propositions on a sample of 38,655 individuals from 23 different countries obtained from the latest data available from the World Values Survey Group’s survey. We found that conscientiousness and agreeableness were both negatively associated with willingness to justify unethical behavior. (...) We also conducted Hierarchical Linear Modeling and found significant interaction effects of selected GLOBE cultural dimensions on the relationships between personality traits and willingness to justify unethical behavior. We provide managerial implications of our findings, as well as suggestions for future research. (shrink)